home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9407a.zip
/
M9470126.TXT
< prev
next >
Wrap
Text File
|
1994-07-02
|
3KB
|
44 lines
Document 0126
DOCN M9470126
TI Incidence and morbidity of infection by hepatitis C virus in children
with acute lymphoblastic leukaemia.
DT 9409
AU Dibenedetto SP; Ragusa R; Sciacca A; Di Cataldo A; Miraglia V; D'Amico
S; Lo Nigro L; Ippolito AM; Division of Paediatric Haematology-Oncology,
University of; Catania, Italy.
SO Eur J Pediatr. 1994 Apr;153(4):271-5. Unique Identifier : AIDSLINE
MED/94252360
AB A group of 90 patients with acute lymphoblastic leukaemia (ALL) in first
continuous complete remission (CCR), admitted in our hospital between
January 1986 and September 1992, were tested for the presence of
antibodies against hepatitis C virus (HCV), antibodies against hepatitis
B virus and antibodies against HIV-1 during maintenance therapy or
thereafter. They were compared with a group of 71 children with other
malignancies in first CCR who had been diagnosed consecutively from
January 1986 to September 1992. No patient with ALL or any other
malignancy was found to be positive for hepatitis B surface antigen or
HIV-1. HCV-specific antibodies were detected in 28 out of 87 children
(32.1%) with ALL and in 4 out of 44 patients (9%) with malignancies
other than ALL who had received at least one transfusion of blood or
platelets (P < 0.01). HCV-specific antibodies were also detected in one
out of three untransfused children with ALL but in none of the
untransfused children with malignancies other than ALL. HCV-specific
seropositivity influenced the management of children with ALL during
maintenance therapy. In fact, as a result of abnormal liver function
tests, maintenance therapy had to be suspended significantly more often
in the case of HCV-seropositive patients with ALL than in
HCV-seronegative ones. Despite the high morbidity during maintenance
therapy, chronic liver disease (CLD) was uncommon in both groups: five
children with ALL (17.2% of HCV-seropositive children) and one child
with a malignancy other than ALL (25%) had CLD.(ABSTRACT TRUNCATED AT
250 WORDS)
DE Adolescence Child Child, Preschool Chronic Disease Hepatitis
Antibodies/BLOOD Hepatitis C/*EPIDEMIOLOGY/ETIOLOGY/IMMUNOLOGY Human
Incidence Infant Infant, Newborn Leukemia, Lymphocytic,
Acute/*COMPLICATIONS Liver Diseases/ETIOLOGY Liver Function Tests
Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).